Debrecen - Hortobágy - Hajdúszoboszló

Debrecen is the second most populous city in the country. The centre of the Reformed Church of Hungary. It is famous for its Nágyerdő ("Big Forest") Park, which has a large thermal water spa. It is one of the most popular spas in the country. The town's sights include the Golden Bull, the oldest functioning hotel in the country, the Classicist town hall, the Greek Catholic church, St. Anna's cathedral, the old mill and the country's largest Classicist Reformed cathedral.

Hortobágy — the largest Hungarian national park, listed by UNESCO as a World Cultural Heritage Site. Folk Craft Museum, Museum of Tabunks, Charda Museum.

Hajdúszoboszló is known as the «Mecca of rheumatics». The thermal water, flowing from 1,100 metres below the surface, cures many musculoskeletal system diseases, as well as dermatological conditions and gynaecological disorders.